DRUG	SUPPLIED	DOSE	COMMENTS
CYPROHEPTADINE (Paeds) (Periactin) Mechanism of action: Antihistamine Ref: 1, 21, 420 Last update: 2019-01-16	Tablet: 4 mg	Cyclic Vomiting Syndrome (CVS) Prophylaxis: 0.125-0.25 mg/kg/dose PO BID or TID (Max 0.5 mg/kg/day) Appetite Stimulant: 0.125 mg/kg/dose PO div BID	CVS prophylactic dosing is for children < 5 yrs old, use amitriptyline for >5 yrs old. anticholinergic side effects including increased appetite, weight gain, sedation. paradoxical hyperexcitability may occur in some children. For use as an appetite stimulant, a dosing cycle of 13 weeks on therapy, followed by 1 week off therapy may enhance efficacy. Standard Prescription: cyproheptadine__mg PO__(frequency) (__mg/kg/day)