| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| GENTAMICIN (Paeds) Mechanism of action: Aminoglycoside antibiotic Ref: 6, 44, 188 Last update: 2022-07-03 |
injection: 10 mg/mL, 40 mg/mL | Children: Traditional: 2.5 mg/kg/dose IV Q8H. Synergy in combination with other antibiotic: 1 mg/kg/dose IV Q8H. Extended interval: 7 mg/kg/dose IV once daily Adult: 1-2.5 mg/kg/dose IV Q8H. Gastrointestinal tract decontamination in intestinal failure : 5 mg/kg/dose PO BID x 1-2 weeks |
Extended interval dosing should NOT be used in patients with renal dysfunction (GFR <90), CF patients, endocarditis, surgical prophylaxis, burns >20% of body or in Gram positive infections where aminoglycoside is being used with another antibiotic for synergy Adjust dose in renal impairment. Obtain baseline creatinine; for therapy beyond 7 days check creatinine at least twice weekly Administer extended interval and traditional interval doses over 30 min. Dose may be adjusted based on serum concentrations. Therapeutic serum concentrations: Traditional dosing: Trough (pre-dose): < 2 mg/L Peak (post-dose): 6-10 mg/L Extended interval dosing: Trough (pre-dose): < 1 mg/L No peak (post-dose) level is required. See Supplementary Materials for Therapeutic Drug Monitoring Table (white pages in print copy) Standard Prescription: gentamicin __mg IV Q H (__mg/kg/24 hour) |