DRUG	SUPPLIED	DOSE	COMMENTS
DIAZEPAM (Paeds) (Valium, Diastat) Mechanism of action: Benzodiazepine. Diezepam is a positive allosteric modulator of the GABA type A receptors reducing the arousal of the cortical and limbic systems in the central nervous system Ref: 32, 44, 336, 364, 556 Last update: 2022-06-19	tablet: 2 mg, 5 mg, 10 mg injection: 10 mg/2 mL amp (contains propylene glycol) (Also available but not stocked at BCCH: Diastat 5 & 10 mg pre-loaded syringe for rectal administration.)	Sedation or muscle relaxation: 0.04-0.2 mg/kg/dose PO Q6-8H. Maximum: 10 mg/dose Status Epilepticus: 0.3 mg/kg/dose IV or 0.5 mg/kg/dose PR. IV or PR dose may be repeated in 5-10 min. if required. Maximum single IV dose: < 5 yr: 5 mg IV >= 5 yr: 10 mg IV Maximum single PR dose: 20 mg PR	Injectable product may be given rectally. IV administration rate of undiluted injection not to exceed 5 mg/min. Adverse effects (IV): Hypotension, respiratory depression (especially following rapid IV administration). Standard Prescription: diazepam__mg IV/IM{PO} Q__H (__mg/kg/dose) (prn) diazepam__mg IV{PR} x 1 dose  (__mg/kg/dose). May repeat in 10 min prn (max 3 doses)