DRUG SUPPLIED DOSE COMMENTS
DIAZOXIDE (Paeds)
(Proglycem)

Mechanism of action:

Antihypoglycemic. Inhibits the secretion of insulin by opening ATP-sensitive potassium channel of beta cells of the pancreas.

Diazoxide is also used as a vasodilator in the treatment of acute hypertension or malignant hypertension.




Ref: 1, 44,  209, 533



Last update: 2021-12-04		 capsule: 100 mg (not stocked at BCCH)
liquid (BCCH): 50 mg/mL oral suspension.

50 mg/mL suspension can be obtained through the Health Canada Special Access Program (longer stability than BCCH compounded suspension).		 Hyperinsulinemic hypoglycemia:
Infants: 1.6-5 mg/kg/dose PO Q8H (5-15 mg/kg/24 h)
Children: 1-2.5 mg/kg/dose PO Q8H OR 1.5-4 mg/kg/dose PO Q12H (3-8 mg/kg/24 hr)		 Adverse effects include: heart failure from salt and water retention, hyperglycemia, hyperuricemia, hypertrichosis.

Consider adding hydrochlorothiazide.

IV dosage form was discontinued by the manufacturer in 2003.

Consultation with Endocrinology before starting is recommended.

Renal impairment: consider decreased dose.

Caution in neonates with hyperbilirubinemia.

Standard Prescription:

diazoxide__mg PO Q__H (__mg/kg/24hr)