DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
DIMENHYDRINATE (Paeds) (Gravol) Mechanism of action: Antihistamine, used as antiemetic and mild sedative Ref: 1, 44, 516, 517 Gouin S, Vo TT, Roy M et al. Oral dimenhydrinate versus placebo in children with gastroenteritis: a randomized controlled trial. Pediatric 2012;129:1050-5 Kranke P, Morin M, Roewer N et al. Dimenhydrinate for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomized controlled trials. Acta Scand 2002;46:238-44. Last update: 2021-12-03 |
tablet: 50 mg chewable tablet: 15 mg syrup: 3 mg/mL suppository: 25 mg, 50 mg, 100 mg injection: 10 mg/mL (IV), 50 mg/mL (IM) |
Children < 12 years old: 0.5-1.25 mg/kg/dose PO/IV/IM/PR Q6H PRN 2-6 years old: 75 mg/24 hr. 6-12 years old: 150 mg/24 hr. Maximum IM/IV Dose: 300 mg/24 hr. Adults: 25-50 mg/dose PO/IV/IM Q4-6H PRN. |
Drowsiness, dizziness, dry mouth. Irritation at injection site - rotate sites. Paradoxical excitement may occur in young children. Standard Prescription: dimenhydrinate__mg IV/PO Q__H PRN___ (__mg/kg/24hr) |