| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| DIPYRIDAMOLE (Paeds) (Persantine) Mechanism of action: Antiplatelet; vasodilator. Dipyridamole: 1) inhibits the phosphodiesterase enzymes that normally break down cAMP (increasing cellular cAMP levels and blocking the platelet aggregation response to ADP) and/or cGMP. 2) inhibits the cellular reuptake of adenosine into platelets, red blood cells, and endothelial cells, leading to increased extracellular concentrations of adenosine. Ref: 90, 149 Last update: 2019-01-22 |
tablet: 25 mg, 50 mg, 75 mg |
Children: 2-5 mg/kg/24 hr PO div. TID. Post-op Ventricular Assist Device (Berlin Heart): 1 mg/kg/dose PO Q6H |
ASA alternative. Variable oral absorption; to optimize take on an empty stomach (1 hour before or 2 hours after meals) Has peripheral vasodilator effects: use with caution in patients with hypotension In patients with Berlin Hearts dipyridamole is used in combination with ASA as part of Berlin Heart anticoagulation protocol - see Berlin Heart on Team site at BCCH Standard Prescription: dipyridamole__mg PO Q__H (__mg/kg/24hr) |