| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| DISOPYRAMIDE (Paeds) (Rythmodan) Mechanism of action: Class Ia antiarrhythmic, prolongs QRS and QT durations. targets sodium channels to inhibit conduction. Ref: 44, 192 Last update: 2019-01-22 |
capsule: 100 mg oral suspension (BCCH): 1 mg/mL, 5 mg/mL, 10 mg/mL |
Children: < 1 yr old: 2.5-7.5 mg/kg/dose PO QID 1-4 yr old: 2.5-5 mg/kg/dose PO QID 4-12 yr old: 2.5-4 mg/kg/dose PO QID 12-18 yr old: 1.5-4 mg/kg/dose PO QID Adults: < 50 kg: 100 mg PO Q6H > 50 kg: 150 mg PO Q6H If no response, may increase dose to 200 mg PO Q6H (adults) |
Occasionally used for obstructive cardiomyopathy. Negative inotropic effects. Some anticholinergic side effects may occur (dry mouth, urinary hesitancy). Decrease dose in renal failure Interacts with erythromycin, clarithromycin, antifungals to increase levels of disopyramide resulting in increased risk of cardiotoxicity (major cytochrome P450 substrate) Standard Prescription: disopyramide__mg PO Q__H (__mg/kg/24hr) |