DRUG SUPPLIED DOSE COMMENTS
DORNASE ALFA (Paeds)
(Pulmozyme, DNase)

Mechanism of action:

Mucolytic; Enzyme




Ref: 30


Last update: 2022-06-18		 ampoule for inhalation:  2.5 mg/2.5 mL
 Cystic Fibrosis Patients > 5 years:
2.5 mg by inhalation once daily. (Preferably after morning physiotherapy.)

Some patients may benefit from BID dosing.
Store in refrigerator.

Response to dornase is highly variable; a 3 month therapeutic trial is reasonable but continued treatment should be based on clear clinical response.

Do not mix with other medications in the nebulizer.

Used in patients < 5 years for resolution of persistent atelectasis as a 1-2 month trial.

Standard Prescription:

dornase alfa 2.5 mg inh via nebulizer__(frequency)