DRUG SUPPLIED DOSE COMMENTS
ETHAMBUTOL (Paeds)
(Etibi)

Mechanism of action:

Antimycobacterial agent. It is bacteriostatic against actively growing bacilli. It inhibits the enzyme arabinosyl transferase leading to increased permeability of the cell wall.



Ref: 6, 44, 134, 167, 203



Last update: 2022-06-24		 tablet: 100 mg, 400 mg Tuberculosis and Non-TB mycobacterial infections:  

15 -25 mg/kg/dose PO daily or 50 mg/kg/dose twice weekly. 
Maximum:  2.5 g/dose.
Adverse effects: optic neuritis (usually reversible), decreased red/green colour discrimination, GI upset and hypersensitivity.

Avoid use in children in whom visual acuity and color perception cannot be assessed.

Commonly given concurrently with rifampin or other TB drugs.

Standard Prescription:

ethambutol__mg PO__(frequency) (__mg/kg/dose)