| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| NOREPINEPHRINE (Paeds) (Noradrenalin) Mechanism of action: Alpha-1 and beta-1 adrenergic agonist Ref: 32, 44, 401 Last update: 2019-07-15 |
Injection: 4 mg (base)/4 mL ampoule Standard Concentrations for Critical Care: 25 mcg/mL, 50 mcg/mL, 200 mcg/mL, 500 mcg/mL, |
Hypotension/shock: Infants and Children: 0.02 - 0.1 mcg/kg/min Titrate to desired effects, Max: 1-2 mcg/kg/min. |
Correct intravascular volume before initiating norepinephrine. May cause tachycardia, dysrhythmias, headache Central line is preferred. Extravasation can cause tissue necrosis. For treatment of extravasation: Phentolamine 0.1 mL of 0.5 mg/mL is infiltrated intradermally around the site; see phentolamine monograph. Do not give phentolamine IV as hemodynamic instability may result. See the Extravasation Policy on PHSA SHOP Standard Prescription: norepinephrine __mcg/kg/min continuous IV infusion |