DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
GANCICLOVIR (Paeds) (Cytovene) Mechanism of action: Antiviral; acyclic analog of guanosine Ref: 6, 44 Last update: 2022-07-02 |
injection: 500 mg/vial |
Treatment of CMV disease: 5 mg/kg/dose IV Q12H for a minimum 14-21 days and until plasma CMV PCR negative CMV preemptive therapy/treatment of asymptomatic viremia: 5 mg/kg/dose IV Q12H CMV prophylaxis for post-solid organ transplant: 5 mg/kg/dose IV once daily x 7 days/week or 6 mg/kg/dose IV once daily x 5 days/week |
First line for CMV infection. Dose reduction required in renal impairment and hemodialysis patients (see Parenteral Manual online). 5 day per week dosing schedule allows patients to receive IV therapy as out-patients Use valganciclovir orally as there is no oral formulation of ganciclovir. Note: valganciclovir can NOT be substituted for ganciclovir on a one-to-one basis. Standard Prescription: ganciclovir__mg IV q__h (__mg/kg/24hr) |