DRUG SUPPLIED DOSE COMMENTS
HEPARIN (Paeds)
(Unfractionated Heparin, UFH)

Mechanism of action:

Anticoagulant



Ref: 90, 149



Last update: 2023-09-13		 injection: 100, 1000, 10,000 unit/mL
1 and 2 mL amp., 1, 5, 10 mL vials
25,000 units/500 mL D5W bag (50 U/mL)		 Pediatrics:
Loading Dose: 75 units/kg IV bolus (max: 5000 units)
Initial Maintenance (continuous IV infusion):
<= 1 year old: 28 units/kg/hr
>1 year old: 20 units/kg/hr
"Low dose" 10-15 U/kg/hr

Adolescent and adult:
18 units/kg/hr (max: 1000 units/hr)
Adjust dose to maintain APTT in range of 1.5 to 2.5 times control (60-85 sec).

Major toxicities are bleeding, allergy, thrombocytopenia.

Refer to Protocols for Anticoagulant and thrombolytic therapy in References and Supplementary Materials


Standard Prescription:

heparin infusion (50 units/mL) in D5W; infuse IV at__mL/hr (__units/kg/hr)