DRUG	SUPPLIED	DOSE	COMMENTS
HYDROXYUREA (Paeds) (Hydrea) Mechanism of action: Ref: 44, 548, 549, 550 Last update: 2022-07-03	Capsules: 500 mg Oral Suspension (BCCH): 100 mg/mL	Sickle cell anemia: Initial: 20 mg/kg/dose PO daily. Increase by 5 mg/kg/dose every 8 weeks as needed Maximum 35 mg/kg/dose PO daily Hyperleukocytosis during treatment of acute promyelocytic leukemia: 30 mg/kg/dose PO QID. Max 1000 mg/dose Hyperleukocytosis secondary to chronic myeloid leukemia: 20-25 mg/kg/dose PO TID-QID. Max 6000 mg/day	Monitor white blood cell count and adjust dose accordingly. For sickle cell anemia, may take 3-6 months for clinical response. Standard Prescription: HYDROXYUREA __mg PO daily/BID/TID (__mg/kg/24hr)