DRUG SUPPLIED DOSE COMMENTS
ITRACONAZOLE (Paeds)
(Sporanox)

Mechanism of action:

Azole antifungal



Ref: 6, 44, 270


Last update: 2022-07-03		 capsule: 100 mg
oral solution: 10 mg/mL		 Children:  
5 mg/kg/dose PO once to twice daily.  Usual maximum:  200 mg BID.

Allergic bronchopulmonary aspergillosis in cystic fibrosis:
5 mg/kg/dose PO once to twice daily.  

Fungal prophylaxis in at-risk immunosuppressed patients (ie. HSCT):
2.5 mg/kg PO BID

Adults:  
200 mg PO once to twice daily
Oral solution and capsule dosage should NOT be used interchangeably.

Administer capsules immediately after a full meal for maximal absorption. Oral solution should be taken on an empty stomach (1 hour before or 2 hours after meals) for maximal absorption.

Consider therapeutic drug monitoring of trough levels if prolonged treatment duration for invasive fungal disease is needed.

Grapefruit decreases itraconazole absorption whereas acidic beverages such as colas or cranberry juice enhances absorption.

Use with caution in patients with hepatic impairment and active/prior congestive heart failure.

Potent inhibitor of CYP3A4 enzyme with many important drug interactions (e.g. may increase plasma levels of phenytoin, carbamazepine, cyclophosphamide, cyclosporine, phenobarbital, tacrolimus, vincristineif used concomitantly.

Adverse Effects: nausea and vomiting,hypertriglyceridemia, hypokalemia and elevated hepatic aminotransferases.


Standard Prescription:

itraconazole__mg  PO Q__H (__mg/kg/24hr)