DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
AMIODARONE (Paeds) (Cordarone) Mechanism of action: Class III antiarrhythmic, alpha and beta blocker. Ref: 1, 15, 37, 55, 141, 588 Last update: 2022-06-09 |
tablet: 200 mg oral liquid (BCCH): 5 mg/mL injection: 50 mg/mL (3 mL amp.) |
Loading Dose: Children PO: <1 yr: 600-800 mg/1.73 m2/24 hr PO div Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance). >= 1 yr: 10-15 mg/kg PO div. Q12-24H X 4-14 days (until adequate control achieved then reduce to maintenance). Children IV: Post-op cardiac surgery patients: 2-5 mg/kg/dose IV over 20-30 min Inadequate response: 1 mg/kg/dose IV over 10 min Adequate response: begin maintenance infusion PALS/ACLS: 5 mg/kg/dose IV/IO rapid bolus for pulseless VT or VF; infuse over 20-30 min for perfusing tachycardias (max 300 mg/dose); may repeat X 2 doses Maintenance: Children PO:<1 yr: 200-400 mg/1.73 m2/24 hr PO div. Q12-24H. >= 1 yr: 5 mg/kg/24 hr PO div. Q12-24H Children IV: 5-15 mcg/kg/min. IV continuous infusion to maximum of 15 mcg/kg/min or 20 mg/kg/24hr. |
Long t½, extensive distribution. IV loading dose can cause bradycardia, hypotension, nausea and vomiting. IV loading doses < 2 mg/kg have less incidence of adverse hemodynamic consequences. Continuous ECG monitoring is recommended while receiving IV amiodarone Significant drug interactions exist, especially with drug metabolized by CYP450 (e.g. warfarin and digoxin); consult Micromedex for a complete list. Use with caution in patients with hepatic dysfunction. NOTE: In some clinical situations, maximum dosages may need to be exceeded. This should only be done in consultation with Cardiology. Standard Prescription: IV Loading Dose: _ mg IV over _ min (_mg/m2/dose) |