DRUG SUPPLIED DOSE COMMENTS
LABETALOL (Paeds)
(Trandate)

Mechanism of action:

Alpha and beta adrenergic blocker.


Ref: 1, 44, 60, 193, 261



Last update: 2022-07-04		 tablet: 100 mg, 200 mg
injection: 5 mg/mL, 20 mL multi-dose vial.
BCCH suspension: 10 mg/mL		 Oral: initial dose: 0.5-1.5 mg/kg/dose BID. Titrate to effect or maximum dose of 5-6 mg/kg/dose BID, Maximum 1200 mg per day.

Hypertensive Emergencies:
IV bolus Dose: 0.2-1 mg/kg/dose IV. Maximum40 mg/dose. May be repeated at 10 min. intervals until desired BP has been achieved.

Continuous IV infusion: 
0.25 mg/kg/hr; rate may be increased by increments of 0.5 mg/kg/hr as needed to control BP to a maximum rate of 3 mg/kg/hr.
 Alpha and beta adrenergic blocker.

Can cause postural hypotension.

Contraindicated in asthma/bronchospasm, 2nd and 3rd degree heart block, cardiogenic shock, severe bradycardia, uncontrolled heart failure.

IV to be given in Critical Care areas and 3F only.

Oral bioavailability is 25% (extensive first-pass metabolism). Bioavailability is increased in liver disease.

BP effects can persist up to 24 hours after stopping IV infusion.


Standard Prescription:

labetalol__mg PO Q__H (__mg/kg/24hr)

labetalol__mg IV loading dose over 2 minutes (__mg/kg/dose)

labetalol__mg/kg/hr continuous IV infusion