DRUG	SUPPLIED	DOSE	COMMENTS
L-ARGININE (Paeds) Mechanism of action: Amino acid Ref: 32, 61, 110, 151 Last update: 2019-04-08	powder injection: 250 mg/mL, 30 mL amps	Oral: Weight < 20 kg: 100-700 mg/kg/24 hr added to daily formula Weight > 20 kg: 2.5-15.4 g/m 2 /24 hr PO added to daily formula. Max 6 g/day I.V.: Weight < 20 kg: Load: 200-600 mg/kg/dose IV over 90 min. Maintenance: 200-600 mg/kg/day by continuous IV infusion. Weight > 20 kg: Load: 3.6-7.2 g/m 2 /dose IV over 90 min. Maintenance: 3.6-7.2 g/m 2 /dose by continuous IV infusion over 24 hours. Max 12 g/day Acute Stroke Like Episodes (MELAS): 250 mg/kg/dose IV BID-QID Max: 1000 mg/kg/day Pituitary Function Test: 0.5 g/kg/dose	If total daily dose is not added to the child's daily formula, then it may be divided BID-TID. for continuous IV infusion, L-arginine is combined in the same IV bag as sodium benzoate and sodium phenylacetate in D10W. pre-treatment with IV ondansetron prior to IV loading dose is recommended; followed by PRN doses. supplemental potassium may be required; monitor. KCl is usually added to the continuous IV infusion mixture at 20 mmol/L. Standard Prescription: L-arginine__g PO__(frequency) (__g/kg/24hr) or (__g/m2/24hr) L-arginine __g IV (__g/kg/dose) x 1 loading dose L-arginine__g IV Q__H (__g/kg/dose) or (__g/m2/24hr)