DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
VANCOMYCIN (Paeds) (Vancocin) Mechanism of action: Glycopeptide antibiotic Ref: 6, 44, 56, 171, 172 Last update: 2024-04-13 |
capsule: 125 mg, 250 mg oral solution (BCCH): 10 mg/mL injection: 500 mg/vial |
Infants and Children: 15 mg/kg/dose IV Q6H. Meningitis or other Serious Infection: 15 mg/kg/dose IV Q6H May consider 20 mg/kg/dose IV Q6H if seriously ill and normal renal function. Clostridium difficile Colitis: Children: 10 mg/kg/dose PO/NG QID x 10-14 days. Maximum 125 mg/dose Adults: 15-20 mg/kg/dose IV Q8-12H. A loading dose of 20-25 mg/kg/dose IV can be given in seriously ill patients. Adults (C. difficile colitis): 125 mg PO/NG QID X 10-14 days. May increase to 500 mg/dose PO/NG QID if complicated C. difficile infection with ileus or toxic megacolon. |
Dose adjustments are required for renal impairment. Metronidazole is preferred therapy for antibiotic-associated colitis; vancomycin should be avoided due to the emergence of vancomycin-resistant enterococcus; if vancomycin is indicated, use oral form only as parenteral vancomycin does not achieve adequate concentrations in gut. Refer to BCCH C difficile Guideline. Consider AUC/MIC monitoring with peak and trough levels. Refer to Therapeutic Drug Monitoring Table and Vancomycin AUC/MIC Therapeutic Drug Monitoring Guideline (in References and Supplementary, white pages in print copy). Standard Prescription: vancomycin __mg IV Q__H (__mg/kg/24hr) vancomycin__mg PO Q__H (__mg/kg/24hr) |