DRUG SUPPLIED DOSE COMMENTS
LINEZOLID (Paeds)
(Zyvoxam)

Mechanism of action:

Oxazolidinone antibiotic: inhibits bacterial protein synthesis to prevent formation of 70S initiation complex



Ref: 6, 44, 211



Last update: 2022-07-05
injection: 2 mg/mL (300 mL)
tablet:
600 mg
Children < 12 years:
10 mg/kg/dose PO/IV Q8H

> 12 years old and Adults:
10 mg/kg/dose PO/IV Q12H

Maximum: 600 mg/dose
Bioavailability 100%

Reversible, nonselective MAO inhibitor. Check for drug interactions

Thrombocytopenia, anemia, leucopenia, pancytopenia reported with duration of therapy > 10 days. Monitoring CBC weekly during long-term therapy is recommended.


Standard Prescription:

linezolid__mg IV/PO Q__H (__mg/kg/24hr)