DRUG SUPPLIED DOSE COMMENTS
LORAZEPAM (Paeds)
(Ativan)

Mechanism of action:

Benzodiazepine



Ref: 4, 44, 83, 336, 557



Last update: 2022-07-05
sublingual tablet: 0.5 mg, 1 mg, 2 mg
suspension (BCCH): 0.4 mg/mL
injection: 4 mg/mL (1 mL)

Standard concentrations for Critical Care:
PICU: 0.2 mg/mL		 Anxiolytic:
0.05 mg/kg/dose PO/SL/IV/IM Q4-8H.
Maximum : 2 mg/dose

Pre-Procedure Sedation:
0.05 mg/kg/dose SL/IM 2 hr before procedure.
Maximum: 4 mg/dose.

Status Epilepticus:
0.1 mg/kg/dose IV/IO. (Max: 4 mg/dose)
May repeat in 5 - 10 min.

Seizure Rescue:
0.1 mg/kg/dose SL (Max: 4 mg/dose).
May repeat in 10 min.		 Sublingual tablets can be given orally.

IV administration rate not to exceed 2 mg/min.

For anxiety, benzodiazepines are for symptomatic treatment only, and alternative strategies to replace benzodiazepine use should be sought quickly.

Doses higher than those used as an anxiolytic may be required for treatment of catatonia consult specialist.

Does not undergo oxidative metabolism.

Dosage adjustment not required for patients with impaired hepatic function.

Benzodiazepines are habit-forming, commonly abused, and have a significant street value.

Midazolam is the preferred agent for rescue of prolonged seizures if using non-IV route.


Standard Prescription:

lorazepam__mg PO/SL/IV q__h (__mg/kg/dose) (prn)

lorazepam__mg PO/SL/IV x 1 dose (__mg/kg/dose)