| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| LOXAPINE (Paeds) (Loxapac) Mechanism of action: Typical antipsychotic Ref: 4, 32, 44, 83, 112, 689 Last update: 2023-05-12 |
tablet: 5 mg, 10 mg, 25 mg, 50 mg injection: 50 mg/mL |
Adolescents/Adults: Initial: 5-10 mg PO BID Increment: Increase over 7-10 days to effective control of psychotic symptoms. Usual Therapeutic & Maintenance Dose: 10-25 mg PO BID Usual maximum: 100 mg/24 hr Usual IM Dose: 10-20 mg IM Q6H Acute agitation: 0.1-0.2 mg/kg/dose PO/IM once Maximum 25 mg/dose |
Medium potency conventional antipsychotic. High incidence of sedation, moderate effects on the cardiovascular system and a moderate incidence of anticholinergic side effects. Moderate incidence of extrapyramidal symptoms (EPS), including dystonic reactions in children and adolescents (treat with benztropine or diphenhydramine). 15 mg loxapine PO approx. = 100 mg chlorpromazine PO or 2 mg haloperidol PO. For the management of acute agitation, refer to relevant departmental guidelines or to the Child Health BC Least Restraint Guideline for more information Standard Prescription: loxapine__mg PO/{IM} Q__H |