DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
AMIKACIN (Paeds) (Amikin) Mechanism of action: Aminoglycoside antibiotic Ref: 6, 44, 184 Last update: 2022-06-08 |
Injection: 250 mg/mL |
Children: Traditional: 7.5 mg/kg/dose IV/IM Q8H Maximum initial dose: 1500 mg/24 hr. Dose may be increased based on serum level Extended interval: 15-20 mg/kg/dose IV Q24H Cystic Fibrosis: 7.5-10 mg/kg/dose IV Q8H. Maximum initial dose: 500 mg/dose. Dose may be increased based on serum level |
Aminoglycoside antibiotic: ototoxic, nephrotoxic. Adjust dose in renal impairment Obtain baseline creatinine; for therapy beyond 7 days check creatinine at least twice weekly. Dose may be adjusted based on serum concentrations. Traditional dosing serum concentrations: Peak (Post-dose): 20-35 mg/L; Trough (Pre-dose): < 10 mg/L. Extended interval trough < 2.5 mg/L. Standard Prescription: amikacin__mg IV Q__H (__mg/kg/24 hr) |