DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
MALARONE (Paeds) (ATOVAQUONE / PROGUANIL HCl) Mechanism of action: Antimalarial Ref: 6, 22, 44 Last update: 2022-07-06 |
Tablet (adult): atovaquone 250 mg / proguanil HCl 100 mg (equivalent to proguanil base 87.4 mg) Tablet (pediatric): atovaquone 62.5 mg / proguanil HCl 25 mg (equivalent to proguanil base 21.86 mg) Available but not stocked at BCCH: |
**doses are for adult tablets** Chemoprophylaxis of (chloroquine-resistant) Plasmodium falciparum malaria: <10kg - see Comments* 11-20 kg: 0.25 tablet/dose PO daily 21-30 kg: 0.5 tablet/dose PO daily 31-40 kg: 0.75 tablet/dose PO daily > 40 kg and adults: 1 tablet/dose PO daily Treatment of uncomplicated (chloroquine-resistant) Plasmodium falciparum malaria: 5-8 kg: 0.5 tablet/dose PO daily x 3 days > 8-10 kg: 0.75 tablet/dose PO daily x 3 days > 10-20 kg: 1 tablet/dose PO daily x 3 days > 20-30 kg: 2 tablets/dose PO daily x 3 days > 30-40 kg: 3 tablets/dose PO daily x 3 days > 40 kg and adults: 4 tablets/dose PO daily x 3 days |
Contraindicated in patients with severe renal impairment (CrCl < 30). Should be taken at the same time everyday with food/milky drink to increase absorption. Repeat dose if emesis occurs within 1 hour after administration. Tablets should preferably be swallowed whole, but may be crushed and mixed with condensed milk just prior to administration to mask bitter taste. Common side effects: abdominal pain, nausea, vomiting, diarrhea. May cause mild transient elevation of liver aminotransferase levels. Prophylactic dose should begin 1 day before exposure and continue for 7 days after leaving endemic area. *For chemoprophylaxis in children ≤10 kg, use pediatric tablet: 5-8 kg: 0.5 pediatric tablet/dose PO daily; 9-10 kg: 0.75 pediatric tablet/dose PO daily Standard Prescription: Malarone __ tablet(s) PO daily to be started 1 day before entering endemic area, continue daily throughout stay, and for 7 days after departure. |