DRUG SUPPLIED DOSE COMMENTS
MEPERIDINE (Paeds)
(Demerol, Pethidine)

Mechanism of action:

Opioid analgesic



Ref: 32, 38, 121


Last update: 2022-04-08		 injection: 50 mg/mL, 75 mg/mL, 100 mg/mL
 Amphotericin-induced Chills:
0.25 to 0.5 mg/kg/dose IV x 1 or 2 doses/24 hr.
Not recommended for pain relief.

Meperidine is considered 4th line therapy for ampho-induced chills (after failure of steroids, antihistamine or acetaminophen).

Use with caution in renal failure: Metabolite of meperidine has CNS effects (tremors, seizures).

If used to treat amphotericin-induced chills, consider other concurrent narcotics or CNS depressants being used to avoid excessive sedation.

75 mg IV meperidine = 10 mg IV morphine.

Standard Prescription:

meperidine__mg IV Q__H x__dose(s) (prn) (__mg/kg/dose)