DRUG SUPPLIED DOSE COMMENTS
METRONIDAZOLE (Paeds)
(Flagyl)

Mechanism of action:

Antibiotic; amebicide; antiprotozoal



Ref: 6, 44, 188, 371, 686, 687



Last update: 2023-04-04		 tablet: 250 mg, 500 mg
suspension (BCCH): 50 mg/mL
injection: 5 mg/mL (100 mL)
vaginal cream: 10%		 Children:
5-15 mg/kg/dose  PO/IV Q8H
Max. 500 mg/dose

Perforated Appendicitis:
IV: 30 mg/kg/dose IV Q24H
Max. 1000 mg/dose

PO: 10 mg/kg/dose PO Q8H
Max: 500 mg/dose

Crohn's Disease
10 mg/kg/dose PO BID to TID. Max. 500 mg/dose

Clostridium difficile:  
Children: Mild to moderate infection, first or second episode: 7.5 mg/kg/dose PO QID x 10 days
Severe complicated infection, with vancomycin: 10 mg/kg/dose IV Q8H x 10 days
Max. 500 mg/dose

Vaginal Therapy:  
One applicatorfull PV nightly x 10 days

Gastrointestinal tract decontamination in intestinal failure:
10 mg/kg/dose PO BID x 1-2 weeks

Adults:
500 mg PO/IV BID to TID
 Excellent oral bioavailability of 100%.

Avoid alcohol containing preparations for 24 hr after dose to prevent disulfiram-like reactions.

Refer to BCCH Pediatric C. difficile guidelines and Adult C. difficile guidelines.

Once daily IV dosing used only for perioperative period until able to tolerate oral regimen




Standard Prescription:

metronidazole__mg IV{PO} Q__H (__mg/kg/24hr)

metronidazole vaginal cream: one applicatorful PV__(frequency) x__days