| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| MILRINONE (Paeds) (Primacor) Mechanism of action: Bipyridine phosphodiesterase III inhibitor resulting in positive inotrope effects and vasodilatation Ref: 44, 119 Last update: 2019-07-01 |
Injection: 1 mg/mL, 10 mL vials Standard concentrations: NICU: 100 mcg/mL in D5W Other areas: 100 mcg/mL; 200 mcg/mL; 400 mcg/mL in D5W; |
Inotrope/Vasodilator: Loading dose: 50 mcg/kg/dose IV over 10 min. Maintenance: 0.25-1 mcg/kg/min by continuous IV infusion. *NB: Loading doses in post-op open heart patients require approval from a pediatric intensive care physician. |
Bipyridine phosphodiesterase III inhibitor resulting in positive inotrope effects and vasodilatation. Contraindicated in obstructive cardiac lesions such as pulmonary and aortic stenosis and coarctation of the aorta. Side effects include: headache, dysrhythmias, hypotension, hypokalemia, abnormal liver function tests, tremor, thrombocytopenia (lower incidence than amrinone), bronchospasm. Half-life is about 2 hrs in children with normal renal function. Half-life is prolonged in patients with renal dysfunction. Standard Prescription: milrinone__mcg IV x 1 loading dose milrinone__mcg/kg/min continuous IV infusion |