DRUG SUPPLIED DOSE COMMENTS
NAPROXEN (Paeds)
(Naprosyn)

Mechanism of action:

Non-steroidal anti-inflammatory drug (NSAID)



Ref: 44, 138, 156


Last update: 2022-03-01
tablet: 125 mg, 250 mg
suspension: 25 mg/mL

375 mg and 500 mg tablets are available but not stocked at BCCH

Manufacture of suppositories was discontinued in 2017.		 Children >2 years:
Analgesic: 5-7 mg/kg/dose PO Q8-12H.
Anti-inflammatory (e.g. JIA): 5-10 mg/kg/dose PO div. BID, Max 20 mg/kg/24 hr.


Maximum: 1000 mg/24 hr.

Adults:
Analgesic:
250-500 mg/dose PO BID.

Dysmenorrhea:
500 mg x 1, then 250 mg PO Q6-8H PRN.
Maximum: 1250 mg/24 hr.
 Naproxen is the most common first-line agent for treating JIA

May increase serum levels of digoxin, methotrexate and lithium. May decrease the antiplatelet effects of ASA.

Note: concomitant use of methotrexate and NSAID is a standard of care for treating JIA.

May cause photosensitive vesicular rash in fair skinned children (pseudoporphyria).


Standard Prescription:

Children:
naproxen__mg PO{PR}__(frequency) (__mg/kg/dose) or (mg/kg/24hr)

Adults:
naproxen__mg PO__(frequency) (prn)