DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
AMLODIPINE (Paeds) (Norvasc) Mechanism of action: Dihydropyridine calcium channel blocker Ref: 44, 85, 105, 106, 562, 563, 564 Last update: 2022-06-08 |
Tablet: 5 mg (10 mg tablets are available but not stocked at BCCH). |
Children: 0.1 to 0.6 mg/kg/dose PO once daily. Maximum initial dose: 5 mg.Maximum dose: 10 mg daily. |
Due to long half-life (35-50 hrs) dosage titrations should not be made more frequently than every 3-5 days Maximum effect on blood pressure may not be seen for 3-4 weeks after therapy begun. Peripheral edema adverse effect is dose dependent and more like at doses >5mg daily. Grapefruit may increase plasma concentrations of amlodipine. Standard Prescription: amlodipine__mg PO daily (__mg/kg/dose) |