DRUG	SUPPLIED	DOSE	COMMENTS
OPIUM AND BELLADONNA (Paeds) (B & O suppositories) Mechanism of action: Opioid analgesic and antispasmodic combination Ref: 32, 44 Last update: 2019-08-10	suppository: containing 65 mg powdered opium and 15 mg dry extract of belladonna	Children: Doses not well established. < 5 years old: 1/3 - 1/2 suppository PR Q6H PRN. > 5 years old: 1 suppository PR Q6H PRN. Adults: 1 suppository PR Q6H PRN.	for moderate to severe pain associated with ureteral spasms, not responsive to non-opioid analgesics. side effects of PR opium (e.g. respiratory and/or CNS depression) can be additive when given with systemically-administered opioids or other CNS depressants. Standard Prescription: opium and belladonna    suppository PR Q   H PRN