| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| OXCARBAZEPINE (Paeds) (Trileptal) Mechanism of action: Anticonvulsant; fast sodium channel blocker Ref: 44, 112, 365 Last update: 2019-08-09 |
tablet: 150 mg, 300 mg, 600 mg suspension: 60 mg/mL |
Children > 2 years old: Initial: 4-5 mg/kg/dose PO BID (Max: 300 mg/dose). Increment: 2.5 mg/kg/dose PO BID every 3-7 days. Maintenance: 15-25 mg/kg/dose PO BID. Maximum: < 4 years old: 30 mg/kg/dose PO BID. > 4 years old: 1050 mg/dose PO BID. Adolescents: Initial: 300 mg/dose PO BID. Increment: 150 mg/dose PO BID every 3 to 7 days. Maintenance: 600-750mg/dose PO BID. Maximum: 1200 mg/dose PO BID. Switching from carbamazepine to oxcarbazepine: oxcarbazepine dose = 1.5 x carbamazepine dose. |
Structurally related to carbamazepine and believed to cause less frequent, severe side effects; however hyponatremia is more common than with carbamazepine. 25-35% incidence of cross-sensitivity with carbamazepine. Risk of Stevens Johnson Syndrome. Drug interactions: Inhibits CYP2C19 and induces CYP3A4. Standard Prescription: oxcarbazepine__mg PO Q__H (__mg/kg/24hr) |