| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| ACETAMINOPHEN (Paeds) (Tylenol; Tempra; paracetamol) Mechanism of action: Analgesic. Ref: 32, 44 Last update: 2023-08-16 |
tablet: 325 mg, 500 mg, 80 mg chewable elixir: 32 mg/mL drops: 80 mg/mL suppository: 120 mg, 325 mg, 650 mg injectable: 10 mg/mL (1000 mg/100 mL manufacturer bag) |
1 to 3 months: 10 mg/kg/dose PO Q4H PRN (max 60 mg/kg/day) 20 mg/kg/dose PR Q6H PRN (max 80 mg/kg/day) >3 months: 10 to 15 mg/kg/dose PO Q4H PRN (max 75 mg/kg/day) 20 mg/kg/dose PR Q6H PRN (max 80 mg/kg/day) Usual adult dose: 325 to 650 mg/dose PO Q4 to 6H PRN (max 4 g/24 hr) Intravenous for pain management post-operatively in patients unable to take oral or rectal acetaminophen. >1 month to 2 year: 15 mg/kg/dose IV Q6H PRN (max 60 mg/kg/day) >2 years and < 50 kg: 12.5 mg/kg/dose IV Q4H PRN OR 15 mg/kg/dose IV Q6H PRN (max single dose 750 mg, 75 mg/kg/day not to exceed 3750 mg/day) >2 years and > 50 kg: 12.5 mg/kg/dose IV Q4H PRN OR 15 mg/kg/dose IV Q6H PRN (max single dose 1000 mg, 75 mg/kg/day not to exceed 4000 mg/day) |
Hepatotoxic in overdose, both chronic and acute. Doses apply to normal healthy children (i.e. no hepatic or renal compromise). Rectal administration results in unpredictable serum levels and a much slower onset of action compared to oral. Intravenous formulation is restricted to those who are unable to take acetaminophen orally or rectally and require acetaminophen for post-operative pain management. *limited data for IV use in less than 2 years of age* Standard Prescription: acetaminophen __mg PO {PR} Q__H {PRN} (__mg/kg/dose) |