DRUG SUPPLIED DOSE COMMENTS
AMPHOTERICIN B, LIPOSOMAL (Paeds)
(Ambisome)

Mechanism of action:

Polyene antifungal


Ref: 6, 44, 302, 609



Last update: 2022-06-08		 Injection: 50 mg/vial
3-5 mg/kg/dose IV Q24H.  (Up to 10 mg/kg/24 hr has been used to treat documented mucormycosis infections).

Infuse dose over 1-2 hours

Via inhalation for Cystic Fibrosis:
20 mg nebulized BID on 3 days per week (Mon/Wed/Fri).
 Lipid formulations are associated with less frequent infusion-related reactions and nephrotoxicity compared to amphotericin B deoxycholate.

Potentially nephrotoxic but children have better tolerance than adults. Other adverse effects include hypokalemia, hypocalcemia, hypomagnesemia, chills, vomiting, hepatotoxicity, headache and hypertension.

See amphotericin B monograph (Fungizone) for treatment of infusion reactions.

May use in CF if intolerant to nebulized amphotericin deoxycholate.

Refer to nursing guidelines “Aerosol therapy using mask and nebulizer” on SHOP.



Standard Prescription:

IV
amphotericin B (Liposomal) __mg IV Q__H (__mg/kg/24 hr)

Nebulized
amphotericin B (Liposomal) 20mg nebulized BID on 3 days per week  (Mon/Wed/Fri)