DRUG SUPPLIED DOSE COMMENTS
ETHANOL 99% (Paeds)
(Absolute alcohol, Ethyl Alcohol 99%)

Mechanism of action:

Antidote; competitive inhibitor of alcohol dehydrogenase, preventing formation of toxic ethylene glycol and methanol metabolites. 


Ref: 19



Last update: 2021-12-07
Injection: 99% ethanol; 10 mL ampoules.

Injection for CVC Lock:  70% (prepared by Pharmacy in 5 mL syringe)

 Methanol, ethylene glycol intoxication
**Dilute to 10% ethanol (v/v). Doses expressed as a 10% ethanol solution.

Loading Dose: 7.5 mL/kg/dose IV over 60 minutes.
Maintenance: 1 mL/kg/h continuous IV infusion.

Dose adjustment required for hemodialys.
 For methanol or ethylene glycol intoxication, consult DPIC and refer to DPIC Poison Management Manual. Fomepizole is the preferred antidote.

Titrate to a therapeutic level of 22-32 mmol/L (100-150 mg/dL).

Possible adverse effects include: tiredness, headaches, dizziness, nausea, light-headedness.

Drug interaction with metronidazole. Monitor for flushing, palpitations, tachycardia, nausea, vomiting.



Standard Prescription:

ethanol 10% __mL IV x 1 loading dose (__mL/kg)
ethanol 10% __mL/kg/hr IV infusion