| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| ALFACALCIDOL (Paeds) (1-alpha-hydroxyvitamin D3, One-Alpha) Mechanism of action: A synthetic Vitamin D metabolite which requires hepatic activation; does not require renal activation. Ref: 4, 112 Last update: 2022-06-08 |
capsule: 0.25 mcg oral drops: 2 mcg/mL (1 drop = 0.1 mcg). 10 mL bottle *Use drops within 28 days of first opening bottle* |
Children: 0.01-0.05 mcg/kg/dose PO once daily. Increase dose every 4 to 8 weeks based on clinical response. Usual maintenance dose in children is 0.25-1 mcg once daily. Usual adult maximum: 1-2 mcg once daily |
Synthetic Vitamin D metabolite which requires hepatic activation; does not require renal activation. Dose adjustment based on serum PTH. Usual maximum doses may be exceeded in consultation with nephrology or endocrinology Monitor calcium, phosphate, iPTH, alkaline phosphatase during dose titration. Standard Prescription: alfacalcidol __mcg PO Q__H (__mcg/kg/24hr) |