DRUG	SUPPLIED	DOSE	COMMENTS
ALLOPURINOL (Paeds) (Zyloprim) Mechanism of action: Xanthine oxidase inhibitor. Ref: 44, 116 Last update: 2021-11-08	tablet: 100 mg, 200 mg, 300 mg suspension (BCCH): 20 mg/mL	10 mg/kg/dose PO once daily or 5 mg/kg/dose PO BID if dose is > 300 mg. Maximum: 800 mg/24 hr.	Decrease dose in renal impairment. Allopurinol is metabolized to an active metabolite with a long half-life (18 hr). Allopurinol is the preferred agent in patients with low risk or intermediate of tumor lysis syndrome. Onset of action ( i.e. decrease in uric acid levels) is 24-48 hours. It is not necessary to give allopurinol while treating with rasburicase. Standard Prescription: allopurinol __mg PO ___(frequency) (__mg/kg/24 hr)