DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
PENICILLIN G BENZATHINE (Paeds) (Bicillin-LA) Mechanism of action: Beta-lactam antibiotic. Ref: 6, 112, 244 Last update: 2022-08-24 |
Injection: 1,200,000 IU/2 mL PLS |
Syphilis: Primary, secondary and early latent (<1 year duration): 50,000 units/kg IM once. Late latent (>1 yr duration) or latent syphilis of unknown duration: 50,000 units/kg/dose IM weekly x 3 weeks. Max dose: 2.4 million units/dose. Rheumatic fever - secondary prevention : < 27 kg : 600,000 units IM every 3-4 weeks. > 27 kg : 1.2 million units IM every 3-4 weeks. |
Deep IM injection ONLY. Do not give IV; intravenous administration has been associated with cardiopulmonary arrest and death. Do not inject into or near artery or nerve (may result in neurovascular and neurological damage). Not a substitute for IV penicillin G; used in certain situations only; consult ID service. Warming to room temperature will lessen pain on injection. Provides sustained levels for 2-4 weeks. Standard Prescription: penicillin G benzathine __units IM ___(frequency) (__units/kg/dose) |