| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| ANTI-THYMOCYTE GLOBULIN (horse) (Paeds) (Atgam = antithymocyte globulin = lymphocyte immune globulin [equine source]) Mechanism of action: Immunosuppressant; purified, pasteurized, horse immune globulin Ref: 32, 74, 514 Last update: 2021-11-08 |
injection: 250 mg/5 mL amp. (Atgam®) See separate monograph for Thymoglobuline® = anti-human thymocyte globulin [rabbit source] |
Aplastic Anemia: 40 mg/kg/dose hr IV once daily x 4 days. Hematopoietic Stem Cell Transplant: 20-40 mg/kg/dose hr IV once daily per protocol. |
Not to be confused with rabbit anti-thymocyte globulin, brand name Thymoglobuline Intradermal sensitivity testing (5 mcg/dose intradermally with contralateral saline control) is recommended prior to the administration of the initial dose of ATG, but may not be predictive of future sensitivity reactions Pre-treatment with acetaminophen, steroids and antihistamines may reduce the incidence of rigors, fever, rashes. See separate monograph for Thymoglobuline® = anti-human thymocyte globulin [rabbit source] Standard Prescription: |