DRUG	SUPPLIED	DOSE	COMMENTS
PENTAMIDINE (Paeds) Mechanism of action: Antimicrobial Ref: 6, 13, 44 Last update: 2022-08-24	Injection: 300 mg/vial	Treatment of pneumocysitis jirovecii pneumonia (PCP): 4 mg/kg/24 hr IM/IV daily x 21 days. Prophylaxis of pneumocysitis jirovecii pneumonia (PCP): Inhalation < 5 years old: 9 mg/kg/dose via nebulizer Q4 weeks. Maximum 300 mg/ per dose. > 5 years old: 300 mg via nebulizer Q4 weeks. Intravenous 4 mg/kg/dose IV Q4 weeks. Maximum 300 mg/dose	Second-line for the treatment or prophylaxis of pneumocystis jirovecii pneumonia. May consider for patients who are intolerant to or fail co-trimoxazole. Adverse effects more common with treatment doses: hypoglycemia, nephrotoxicity, hypotension, increased liver enzymes, leukopenia, neutropenia, thrombocytopenia. Cough and bronchospasm may occur with inhalation therapy. Pretreatment with bronchodilator may be beneficial.      Note: inhalation therapy requires special nebulization procedures; contact Respiratory Therapy. Standard Prescription: pentamidine __mg IM/IV ___(frequency) pentamidine __mg via nebulizer ___(frequency)