DRUG	SUPPLIED	DOSE	COMMENTS
PIMOZIDE (Paeds) (Orap) Mechanism of action: Diphenylbutylperidine conventional antipsychotic. Ref: 44, 83, 112 Last update: 2022-04-23	tablet: 2 mg, 4 mg	Tourette syndrome Initial: 1-2 mg PO HS. Increase dose gradually as needed and tolerated to a maximum of 0.2 mg/kg or 8 mg/day.	May cause anticholinergic and extrapyramidal side effects (EPS). Concomitant use of azole antifungals (fluconazole, itraconazole, ketoconazole, voriconazole), antiviral protease inhibitors, macrolide antibioitics (azithromycin, clarithromycin, erythromycin), fluvoxamine, paroxetine, sertraline, tacrolimus, grapefruit juice or other moderate or strong inhibitors of CYP 1A2 or 3A4 are contraindicated as enzyme inhibition by these products may cause significant elevations in pimozide concentrations. Concomitant use of chlorpromazine, citalopram, escitalopram, fluoxetine, moxifloxacin, ziprasidone or other drugs with demonstrated QTc prolongation as one of their effects is contraindicated due to additive effects on QTc prolongation from pimozide. Perform ECG prior to starting therapy and periodically thereafter during dose adjustment. Contraindicated in patients with known congenital or acquired long QT syndrome, family history of this syndrome, or with a history of cardiac arrhythmias or Torsades de Pointes. Standard Prescription: pimozide __mg PO ___(frequency) (__mg/kg/dose)