DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
POSACONAZOLE (Paeds) (Posanol) Mechanism of action: Broad spectrum triazole antifungal. Ref: 6, 44, 93, 265, 266, 267, 268, 269, 270, 612 Last update: 2023-04-17 |
Oral suspension: 40 mg/mL; 105 mL bottles Delayed-release tablet: 100 mg |
Prophylaxis of invasive fungal infections Children 6 mos - 12 yrs Suspension: 4 mg/kg/dose PO TIDDelayed-Release Tablet: 5-7 mg/kg/dose PO BID x 1 day, then 5-7 mg/kg/dose PO daily. Round to nearest 100 mg. Children >= 13 years and adults: Suspension: 200 mg PO TIDPatients who cannot tolerate meals or nutritional supplements: 200 mg PO QID Delayed-Release Tablet: 300 mg PO BID x 1 day, then 300 mg PO once daily thereafter Treatment of Invasive Fungal Infections: Children 6 mos -12 yrs Suspension: 4.5-6 mg/kg/dose PO QID Delayed-Release Tablet: 5-7 mg/kg/dose PO BID x 1 day, then 5-7 mg/kg/dose PO daily. Round to nearest 100 mg. Children >= 13 years and adults:Suspension: 200 mg PO QID or 400 mg PO BID Delayed-Release Tablet: 300 mg PO BID x 1 day, then 300 mg PO once daily thereafter |
Use of posaconazole is approved only for:
Oral suspension should be taken with a high-fat meal (increases AUC ~4x relative to a fasted state), a regular meal or nutritional supplement (increases AUC ~2.6x), or with an acidic carbonated beverage (e.g. cola)(increases AUC ~0.7x). There are multiple, serious/life-threatening drug interactions involving the cytochrome P450 enzymes; check drug interactions before initiating or stopping posaconazole therapy.May cause QT/QTc prolongation; caution when used with agents with a similar effect. Dosage adjustment may be required for mild-to-severe hepatic impairment. Serum posaconazole trough levels may be monitored to ensure targets for prophylaxis (? 0.7 mg/L) and treatment (? 1 mg/L) are met. Levels are processed every Thursday morning at St. Paul’s Hospital; please send levels by Tuesday. Steady state concentrations requires 6-10 days after onset of treatment or change in dose Standard Prescription: posaconazole __mg PO{NG} ___(frequency) |