DRUG	SUPPLIED	DOSE	COMMENTS
ARGATROBAN (Paeds) Mechanism of action: Direct thrombin inhibitor for heparin induced thrombocytopenia Ref: 90, 117, 122, 149 Last update: 2018-11-25	Injection: 250 mg/2.5 mL Vial	Initial dose: 0.75 mcg/kg/min by continuous IV infusion Increments of 0.1-0.25 mcg/kg/min to target PTT 1.5-3x normal range Lower doses in hepatic failure recommended: 0.2 microgram/kg/min by continuous IV infusion Increments of 0.05 mcg/kg/min	Haematology Consult is required for use Direct Thrombin inhibitor for Heparin induced thrombocytopenia Target PTT 1.5-3 x normal range, check PTT 2hr post bolus Risk of bleeding, hypersensitivity discontinue other parenteral anticoagulants prior to initiation caution if increased risk of bleeding (post LP, recent surgery, uncontrolled hypertension) avoid NSAIDs or other antiplatelet agents Standard Prescription: argatroban __mcg (__mcg/kg) IV x 1 dose (loading dose) argatroban __mcg/kg/min continuous IV infusion