DRUG SUPPLIED DOSE COMMENTS
PROCHLORPERAZINE (Paeds)
(Stemetil)

Mechanism of action:

Piperazine phenothiazine antipsychotic.



Ref: 44



Last update: 2022-09-08		 tablet: 5 mg, 10 mg
liquid: 1 mg/mL
suppository: 10 mg
 Anti-emetic dose:
Children
9-13 kg:  2.5 mg/dose PO once daily to BID PRN. Max: 7.5 mg/day
>13-18 kg: 2.5 mg/dose PO BID-TID PRN. Max: 10 mg/day
>18-39 kg: 2.5 mg/dose PO TID or 5 mg/dose PO BID PRN. Max : 15 mg/day
>39 kg: 5-10 mg PO TID-QID PRN. Max : 40 mg/day

 Extrapyramidal symptoms (EPS) and sedation are common in children.

If EPS occurs, discontinue prochlorperazine and treat with diphenhydramine or benztropine

Onset of action: 30-40 min.

Fatal, life-threatening and persistent adverse effects are rare but suggest that prochlorperazine be reserved for use where other agents have been ineffective.



Standard Prescription:

prochlorperazine __mg PO/PR ___(frequency) (__mg/kg/24 hr)

prochlorperazine __mg IM/IV ___(frequency) (__mg/kg/24 hr)