| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| PROPAFENONE (Paeds) (Rhythmol) Mechanism of action: Class Ic antiarrhythmic agent with some beta blocker effect and negative inotropic effects. Ref: 141, 242, 592 Last update: 2022-09-09 |
tablet: 150 mg, 300 mg oral suspension (BCCH): 1.5 mg/mL, 20 mg/mL. |
Infants and children: Oral dosing: 50-65 mg/m2/dose (2.5-3 mg/kg/dose) PO Q8H or Q12H. Usual range: 150-200 mg/m2/24 hr div. Q8H. If required, dose may be increased by 20-30% every 3 days to a maximum of 600 mg/m2/24 hr. (18 - 20 mg/kg/24 hr). |
Class Ic antiarrhythmic. Also has beta blocker effect with negative inotropic effects. Side effects include GI distress, vomiting, unpleasant taste, fatigue, elevated liver enzymes, AV block, bradycardia, proarrhythmia. Monitor QRS duration and PR interval. Has potential to interact with digoxin leading to increased digoxin levels. Standard Prescription: propafenone __mg PO ___(frequency) (__mg/m2/24 hr) propafenone __mg IV (__mg/kg/dose) Q10min to total load of __mg (__mg/kg), then __mcg/kg/min IV infusion |