DRUG	SUPPLIED	DOSE	COMMENTS
PROPOFOL (Paeds) (Diprivan) Mechanism of action: General anesthetic. Ref: 32, 112, 482, 482 Last update: 2019-08-26	injection: 200 mg/20 mL vial (in 10% soybean emulsion). Standard Concentration in Critical Care: 10 mg/mL.	Short term Sedation in Mechanical Ventilation: Children: 20-200 mcg/kg/min IV. Start with bolus of 1-2 mg/kg IV and IV infusion at 100 mcg/kg/min. Titrate by 5-10 mcg/kg/min. Q5min. as needed to achieve desired response with minimum effective dose. Adults: 5-50 mcg/kg/min IV Maintenance of Anaesthesia: 100-300 mcg/kg/min IV. Usual dose: 125-150 mcg/kg/min. Younger children may require larger doses compared to older children and adults. Procedural Sedation: Initial: 0.5 - 2 mg/kg/dose IV followed by 0.5-2 mg/kg/dose as needed to achieve adequate sedation	Not recommended for sedation of pediatric patients. The emulsion vehicle is similar to lipid emulsions such as Intralipid and similar precautions should be observed. Contraindicated in patients with allergies to eggs, soybeans or soy products. For short term (< 24 hours) or intermittent use only. Caution: Prolonged continuous use (> 24 hours) in infants and children may cause Propofol- Related Infusion Syndrome (PRIS): metabolic acidosis, lipemia, hypotension, multi-system organ failure, rhabdomyolysis, cardiovascular collapse. For use in procedural sedation, refer to Procedural Sedation/Analgesia Guidelines in PHSA SHOP Standard Prescription: propofol __mcg/kg/min IV infusion