DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
PROPYLTHIOURACIL (Paeds) (Propyl-Thyracil) Mechanism of action: Anti-thyroid agent. Ref: Last update: 2013-08-29 |
Tablet: 50 mg, 100 mg | Children: Initial: 5 to 7 mg/kg/24 hr PO div. Q8H Maintenance: 1/3 to 2/3 of the initial dose, Q8H Adults: Initial: 300 to 450 mg/24 hr PO div. Q8H Maintenance: 100 to 150 mg/24 hr PO div. Q8H |
Propylthiouracil is no longer recommended as first line therapy because of hepatic and renal toxicity. Begin maintenance when patient is euthyroid (usually after 2 months). Adjust dose to achieve T3, FT4, and TSH serum levels in the normal range. Standard Prescription: propylthiouracil __mg PO Q__H (__mg/kg/24 hr) |