DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
PYRIDOXINE (Paeds) (Vitamin B6) Mechanism of action: Water soluble vitamin Ref: 32, 44, 259, 696 Last update: 2023-01-12 |
tablet: 25 mg injection: 100 mg/mL oral solution (BCCH): 5 mg/mL, 25 mg/mL |
Deficiency: Children: 5-25 mg/day PO x 3 weeks. Adolescents: 10-20 mg/day PO x 3 weeks Drug Induced Neuritis: Treatment: Child: 1-2 mg/kg/dose PO daily (Max: 100 mg/day) Adult: 100-300 mg PO daily Prophylaxis: Child: 1-2 mg/kg/dose PO daily (Max: 50 mg/day) Adult: 25-50 mg PO daily Pyridoxine-Dependent Seizures: Acute Treatment: Infants: 15 mg/kg/dose PO BID (max 300 mg/24 hrs) Children & Adolescents: 10 mg/kg/dose PO BID (max 500 mg/24 hrs) Consider IV route (100 mg/dose) for patients in ICU or intubated (risk of transient apnea). Maintenance: 7.5-15 mg/kg/dose PO BID or 100 mg PO BID Maximum: 300 mg/24 hrs (infants), 500 mg/24 hrs (children & adolescents) Seizure Relapse During Febrile Illness: Dose may be doubled to maximum 60 mg/kg/24 hrs (children) or 500 mg/24 hrs (adolescents/adults) for up to 3 days |
May be given IM or IV if oral administration is not possible. IV administration should be administered in controlled environment due to risk of apnea. Patients on pyridoxine supplementation should have clinical screening for peripheral neuropathy, including assessment of deep tendon reflexes. Long term ( > 2 months) therapy with large doses ( > 2 g/24 hr) can cause sensory neuropathy. PO maintenance dose can be used empirically until biochemical/genetic testing confirms/excludes diagnosis Standard Prescription: pyridoxine __mg PO Q__H (__mg/kg/24 hr) |