DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
VIGABATRIN (Paeds) (Sabril) Mechanism of action: Anticonvulsant, irreversible mechanism-based inhibitor of gamma-aminobutyric acid aminotransferase (GABA-AT), resulting in increased levels of GABA in the brain. Ref: 32, 44 Last update: 2022-09-12 |
tablet: 500 mg (500 mg sachet is available but not stocked at BCCH) |
Infantile Spasms: Initial: 25 mg/kg/dose PO BID Increment: 25 mg/kg/dose PO BID every 2-3 days to desired clinical response Maximum: 75-100 mg/kg/dose PO BID Refractory Focal Seizures (adjunct): Children:Initial: 20 mg/kg/dose PO BID (Max 250 mg/dose) Increment: Increase by 125-250 mg/dose every 7 days to desired clinical response and tolerability. Maximum: 50 mg/kg/dose PO BID Adolescents > 16 years & Adults: Initial: 500 mg/dose PO BID Increment: 250-500 mg/24 hr PO every 7 days to desired clinical response and tolerability.Maximum: 1500 mg/dose PO BID |
A first line drug in the management of infantile spasms. Adjust dose according to tablet increments. Dose adjustment required in renal impairment. May be taken with or without food. Concerns have been raised over the occurrence of visual abnormalities which may be asymptomatic, and the outcome of which has been variable. Irreversible visual field loss may occur. The potential risks and benefits of therapy with vigabatrin should be discussed with the patient/caregiver. Ophthalmology consultation is suggested routinely before and during treatment. Standard Prescription: vigabatrin__mg PO Q__H (__mg/kg/24hr) |