| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| URSODIOL (Paeds) (Urso, ursodeoxycholic acid) Mechanism of action: Gallstone dissolution agent; anticholelithic Ref: 44, 311, 312, 313, 314 Last update: 2019-08-30 |
tablet: 250 mg suspension (BCCH): 25 mg/mL |
TPN-induced cholestasis/biliary atresia: 10 mg/kg/dose PO TID Cystic Fibrosis: 10-15 mg/kg/dose PO BID Prophylactic Therapy of Sinusoidal obstructive Syndrome (SOS) in BMT patients: 15 mg/kg/dose PO once daily or 5-10 mg/kg/dose PO BID beginning 2 weeks prior to transplant. |
May cause diarrhea and worsen malabsorption by decreasing bile salt pool. Aluminum-based antacids (Almagel, Amphogel, Maalox) can bind to ursodiol and decrease its absorption; do not use antacids within 2 hours of ursodiol dose. Take with food. In patients with Primary Sclerosing Cholangitis, maximum dose is 20 mg/kg/day. Monitor liver enzymes and bilirubin while on therapy. Standard Prescription: ursodiol__mg PO__(frequency) (__mg/kg/24hr) |