DRUG SUPPLIED DOSE COMMENTS
AZITHROMYCIN (Paeds)
(Zithromax)

Mechanism of action:

Macrolide antibiotic


Ref: 6, 44, 73, 92, 303, 608, 610


Last update: 2022-06-09		 Tablet:  250 mg

Suspension:  40 mg/mL

Injection:  500 mg/vial		 Children:
PO:

Pneumonia:
Day 1: 10 mg/kg/dose PO x 1 dose
Days 2 to 5: 5 mg/kg/dose PO daily

Pertussis:
Infants 1-5 months: 10 mg/kg/dose PO daily x 5 days
Infants >= 6 months:
Day 1: 10 mg/kg/dose PO x 1 dose
Days 2 to 5: 5 mg/kg/dose PO daily

IV:
10mg/kg/dose IV daily (max: 500 mg/dose)

Cystic Fibrosis for Anti-inflammatory:
Less than 25 kg: 10 mg/kg/dose PO daily 3x/week (Mon/Wed/Fri)
25-40 kg: 250 mg PO daily 3x/week (Mon/Wed/Fri)
40 kg or greater: 500 mg PO daily 3x/week (Mon/Wed/Fri)

Cystic Fibrosis for Nontuberculous Mycobacteria:
10-12 mg/kg/dose PO once daily (Max: 500 mg/dose)

Adults:
Day 1:  500 mg PO/dose x 1 dose
Days 2 to 5:  250 mg PO/dose daily
 Suspension may be administered via enteral tube

Less risk for drug interactions compared to other macrolide antibiotics

IV azithromycin is comparable in cost to IV erythromycin and is simpler to administer (once daily dosing, less vein irritation).

Rare side effect: tinnutis

Standard Prescription:

azithromycin __mg PO{IV} daily x __ days (__mg/kg/24hr)
azithromycin __mg PO x 1 dose day 1, then __mg PO daily days 2 to__