DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
SODIUM POLYSTYRENE SULFONATE (Paeds) (Kayexalate) Mechanism of action: Cation exchange resin that exchanges sodium for potassium across the large intestine Ref: 1, 44 Last update: 2022-09-11 |
powder 1 level teaspoon = 3.5 g of sodium polystyrene sulfonate |
Children: Usual Dose PO: 1 g/kg/dose Q6H (max 15 g/dose)PR: 1 g/kg/dose Q2-6H (max 50 g/dose) Adults: PO: 15-30g once daily-QID (Maximum daily dose=60 grams) PR: 30-50 g Q6H |
Exchange ratio is 1 mmol K+ per gram of resin. Each gram of sodium polystyrene sulfonate contains 4.1 mEq of sodium. Onset of action 2-24 hours. May alter absorption of oral medications:PO administration ideally should be spaced by 3 hours from other medications. Powder: to give orally or by NG/NJ, mix with 3-4 mL water or D5W or D10W per gram of powder. To give rectally, mix to a concentration of 0.3-0.5 gram/mL with D5W. Do not give sorbitol suspension rectally Retain enema in colon for at least 30-60 min. Rectal route of administration is less effective than oral. Can be added to formula under guidance of a dietitian. Add prescribed amount of sodium polystyrene sulfonate to volume of formula. Maximum dose is 6 grams per liter of formula. Stir well, then let stand in fridge for 1 hour. Carefully pour off the top layer, leaving the brown slurry behind. Discard slurry Do not administer with fruit juices containing K+,, antacids or Mg++ containing laxatives (risk of metabolic alkalosis) or Al+++ (risk of intestinal obstruction) Standard Prescription: sodium polystyrene sulfonate__g PO{PR} Q__H |